Article
Factor I autoantibodies in patients with atypical hemolytic uremic syndrome: disease-associated or an epiphenomenon?
Clinical journal of the American Society of Nephrology : CJASN - 1 Mar 2012
Kavanagh David, Pappworth Isabel Y, Anderson Holly, Hayes Christine M, Moore Iain, Hunze Eva-Maria, Bennaceur Karim, Roversi Pietro, Lea Susan, Strain Lisa, Ward Roy, Plant Nick, Nailescu Corina, Goodship Timothy H J, Marchbank Kevin J
Abstract excerpt
BACKGROUND AND OBJECTIVES: Atypical hemolytic uremic syndrome is a disease associated with mutations in the genes encoding the complement regulators factors H and I. In addition, factor H autoantibodies have been reported in ∼10% of patients with atypical hemolytic uremic syndrome. This study searched for the presence of factor I autoantibodies in atypical hemolytic uremic syndrome. DESIGN, SETTING, PARTICIPANTS,...
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