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Article

Limitation of phosphate assimilation maintains cytoplasmic magnesium homeostasis.

Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2021

Bruna Roberto E, Kendra Christopher G, Groisman Eduardo A, Pontes Mauricio H

Abstract excerpt

Phosphorus (P) is an essential component of core biological molecules. In bacteria, P is acquired mainly as inorganic orthophosphate (Pi) and assimilated into adenosine triphosphate (ATP) in the cytoplasm. Although P is essential, excess cytosolic Pi hinders growth. We now report that bacteria limit Pi uptake to avoid disruption of Mg2+-dependent processes that result, in part, from Mg2+ chelation by ATP. We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 33707210
DOI: 10.1073/pnas.2021370118
PMCID: PMC7980370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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