Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Additional impact of mutational genotype on prognostic determination in resistant and relapsed acute myeloid leukaemia.

Leukemia research - 1 Sept 2021

Linch David C, Hills Robert K, Gilkes Amanda, Burnett Alan K, Russell Nigel, Gale Rosemary E

Abstract excerpt

Outcome after failure of initial therapy in younger adult patients with acute myeloid leukaemia (AML) is highly variable. Cytogenetics, length of first remission (CR1) before relapse, and allogeneic transplantation are known prognostic factors, but the contribution of leukaemic genotype is less clear, particularly in resistant disease. Of 5,651 younger adult patients entered into UK MRC/NCRI AML trials between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Combined Chemotherapy Protocols
Share to Cytogenetic Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Follow-Up Studies

Share to Leukemia, Myeloid, Acute

Share to Neoplasm Recurrence, Local

Share to Nucleophosmin

Share to Survival Rate

Source

Identifiers

PMID: 33706968
DOI: 10.1016/j.leukres.2021.106553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Additional impact of mutational genotype on prognostic determination in resistant and relapsed acute myeloid leukaemia.PMID 33706968Read ↗

Prognostic significance of NPM1 mutations in the absence of FLT3-internal tandem duplication in older patients with acute myeloid leukemia: a SWOG and UK National Cancer Research Institute/Medical Research Council report.Semantic proximity Read ↗

Prognostic factors and their importance in relapsed and refractory AML: Comments on "Additional impact of mutational genotype on prognostic determination in resistant and relapsed acute myeloid leukaemia" by Linch et al.Semantic proximity Read ↗

The value of molecular stratification for CEBPA(DM) and NPM1(MUT) FLT3(WT) genotypes in older patients with acute myeloid leukaemia.Semantic proximity Read ↗

Resistance prediction in AML: analysis of 4601 patients from MRC/NCRI, HOVON/SAKK, SWOG and MD Anderson Cancer Center.Semantic proximity Read ↗

Outcome of patients with distinct molecular genotypes and cytogenetically normal AML after allogeneic transplantation.Semantic proximity Read ↗

A randomized comparison of CPX-351 and FLAG-Ida in adverse karyotype AML and high-risk MDS: the UK NCRI AML19 trialSemantic proximity Read ↗

The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trialSemantic proximity Read ↗

A 29-gene and cytogenetic score for the prediction of resistance to induction treatment in acute myeloid leukemia.Semantic proximity Read ↗

Simpson's Paradox and the Impact of Different DNMT3A Mutations on Outcome in Younger Adults With Acute Myeloid Leukemia.Semantic proximity Read ↗

Influence of molecular subgroups on outcome of acute myeloid leukemia with normal karyotype in 141 patients undergoing salvage allogeneic stem cell transplantation in primary induction failure or beyond first relapse.Semantic proximity Read ↗

The prognostic relevance of flt3 and npm1 mutations on older patients treated intensively or non-intensively: a study of 1312 patients in the UK NCRI AML16 trial.Semantic proximity Read ↗

The prognostic impact of FLT3-ITD, NPM1 and CEBPa in cytogenetically intermediate-risk AML after first relapse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.