Article
A 29-gene and cytogenetic score for the prediction of resistance to induction treatment in acute myeloid leukemia.
Haematologica - 1 Mar 2018
Herold Tobias, Jurinovic Vindi, Batcha Aarif M N, Bamopoulos Stefanos A, Rothenberg-Thurley Maja, Ksienzyk Bianka, Hartmann Luise, Greif Philipp A, Phillippou-Massier Julia, Krebs Stefan, Blum Helmut, Amler Susanne, Schneider Stephanie, Konstandin Nikola, Sauerland Maria Cristina, Görlich Dennis, Berdel Wolfgang E, Wörmann Bernhard J, Tischer Johanna, Subklewe Marion, Bohlander Stefan K, Braess Jan, Hiddemann Wolfgang, Metzeler Klaus H, Mansmann Ulrich, Spiekermann Karsten
Abstract excerpt
Primary therapy resistance is a major problem in acute myeloid leukemia treatment. We set out to develop a powerful and robust predictor for therapy resistance for intensively treated adult patients. We used two large gene expression data sets (n=856) to develop a predictor of therapy resistance, which was validated in an independent cohort analyzed by RNA sequencing (n=250). In addition to gene expression...
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