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Article

Tuft-cell-intrinsic and -extrinsic mediators of norovirus tropism regulate viral immunity

1 Nov 2022

Abstract excerpt

Murine norovirus (MNoV) is a model for human norovirus and for interrogating mechanisms of viral tropism and persistence. We previously demonstrated that the persistent strain MNoV CR6 infects tuft cells, which are dispensable for the non-persistent strain MNoV CW3 . We now show that diverse MNoV strains require tuft cells for chronic enteric infection. We also demonstrate that interferon-λ (IFN-λ) acts directly...

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PMID: 36351394
DOI: 10.1016/j.celrep.2022.111593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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