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Article

Hyperactive Behavior and Altered Brain Morphology in Adult Complement C3a Receptor Deficient Mice.

Frontiers in immunology - 1 Jan 2021

Pozo-Rodrigálvarez Andrea, Ollaranta Roosa, Skoog Jenny, Pekny Milos, Pekna Marcela

Abstract excerpt

The C3a receptor (C3aR) is a seven trans-membrane domain G-protein coupled receptor with a range of immune modulatory functions. C3aR is activated by the third complement component (C3) activation derived peptide C3a and a neuropeptide TLQP-21. In the central nervous system (CNS), C3aR is expressed by neural progenitors, neurons as well as glial cells. The non-immune functions of C3aR in the adult CNS include...

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Identifiers

PMID: 33692783
DOI: 10.3389/fimmu.2021.604812
PMCID: PMC7937871

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