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Complement receptor <i>C3ar1</i> deficiency does not alter brain structure or functional connectivity across early life development

2025-04-26

Abstract excerpt

Genetic deletion of the complement C3a anaphylatoxin chemotactic receptor ( C3ar1 ), a key component of the innate immune response, is reported to induce behavioural phenotypes consistent with psychiatric symptomatology in mice, but when and where C3ar1 is needed in the brain is unresolved. These questions are significant because, as a G-protein-coupled receptor, human C3AR1 serves as a potential therapeutic tar...

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Identifiers and source

Literature Corpus work
624b5899-e62d-50ea-bd49-161bfc271eab
DOI
10.1101/2025.04.24.650541
Open publication

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Complement receptor <i>C3ar1</i> deficiency does not alter brain structure or functional connectivity across early life developmentDOI 10.1101/2025.04.24.650541
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