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Article

HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1.

Cancer research - 15 Jan 2018

Yang Yongguang, Leonard Marissa, Zhang Yijuan, Zhao Dan, Mahmoud Charif, Khan Shugufta, Wang Jiang, Lower Elyse E, Zhang Xiaoting

Abstract excerpt

Studies of the estrogen receptor (ER) coactivator protein Mediator subunit 1 (MED1) have revealed its specific roles in pubertal mammary gland development and potential contributions to breast tumorigenesis, based on coamplification of MED1 and HER2 in certain breast cancers. In this study, we generated a mouse model of mammary tumorigenesis harboring the MMTV-HER2 oncogene and mutation of MED1 to evaluate its...

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Share to Cell Transformation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplastic Stem Cells

Share to Receptor, ErbB-2

Share to Receptors, Estrogen

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Source

Open in PubMed Open full text

Identifiers

PMID: 29187405
DOI: 10.1158/0008-5472.CAN-17-1533
PMCID: PMC5771879

Genes

MED1
AREG
IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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