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Article

Systemic Immune Bias Delineates Malignant Astrocytoma Survival Cohorts.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2021

Prosniak Michael, Harshyne Larry A, Gorky Jonathan, Curtis Mark T, Kenyon Lawrence C, Schwaber James S, Lebrun Aurore, Kean Rhonda B, Andrews David W, Hooper D Craig

Abstract excerpt

Patients with grade III anaplastic astrocytomas (AA) separate into survival cohorts based on the presence or absence of mutations in isocitrate dehydrogenase (IDH). Progression to glioblastoma (GBM), morphologically distinguishable by elevated microvascular proliferation, necrosis, and cell division in tumor tissues, is considerably more rapid in IDH wild-type tumors such that their diagnosis as AA is relatively...

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Identifiers

PMID: 33685995
DOI: 10.4049/jimmunol.2000901

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