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Article

Glioma grade is associated with the accumulation and activity of cells bearing M2 monocyte markers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2013

Prosniak Michael, Harshyne Larry A, Andrews David W, Kenyon Lawrence C, Bedelbaeva Kamila, Apanasovich Tatiyana V, Heber-Katz Ellen, Curtis Mark T, Cotzia Paolo, Hooper D Craig

Abstract excerpt

PURPOSE: This study is directed at identifying the cell source(s) of immunomodulatory cytokines in high-grade gliomas and establishing whether the analysis of associated markers has implications for tumor grading. EXPERIMENTAL DESIGN: Glioma specimens classified as WHO grade II-IV by histopathology were assessed by gene expression analysis and immunohistochemistry to identify the cells producing interleukin...

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PMID: 23741072
DOI: 10.1158/1078-0432.CCR-12-1940

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