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Article

Genetic contribution to high temperature tolerance in Cryptococcus neoformans.

Genetics - 3 Mar 2021

Stempinski Piotr R, Zielinski Jessica M, Dbouk Nadir H, Huey Elizabeth S, McCormack Ellen C, Rubin Alexander M, Chandrasekaran Srikripa, Kozubowski Lukasz

Abstract excerpt

The human fungal pathogen Cryptococcus neoformans relies on a complex signaling network for the adaptation and survival at the host temperature. Protein phosphatase calcineurin is central to proliferation at 37°C but its exact contributions remain ill-defined. To better define genetic contributions to the C. neoformans temperature tolerance, 4031 gene knockouts were screened for genes essential at 37°C and under...

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Source

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Identifiers

PMID: 33683363
DOI: 10.1093/genetics/iyaa009
PMCID: PMC8045695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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