Article
KCNJ5 Mutation Contributes to Complete Clinical Success in Aldosterone-Producing Adenoma: A Study From a Single Center.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists - 1 Jul 2021
Zhang Cui, Wu Luming, Jiang Lei, Su Tingwei, Zhou Weiwei, Zhong Xu, Xie Jing, Sun Fukang, Zhu Yu, Jiang Yiran, Wang Weiqing
Abstract excerpt
OBJECTIVE: The KCNJ5 mutation is the most frequent mutation in aldosterone-producing adenoma (APA). We aimed to illustrate the relationship between KCNJ5 and prognosis after adrenalectomy as a guide for further treatment. METHODS: Our study included 458 patients with APA. Tumor tissues were screened for somatic mutations in KCNJ5 hot-spot regions. We performed a retrospective analysis to identify correlations...
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