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Article

Cardiovascular and metabolic characters of KCNJ5 somatic mutations in primary aldosteronism.

Frontiers in endocrinology - 1 Jan 2023

Chang Yi-Yao, Lee Bo-Ching, Chen Zheng-Wei, Tsai Cheng-Hsuan, Chang Chin-Chen, Liao Che-Wei, Pan Chien-Ting, Peng Kang-Yung, Chou Chia-Hung, Lu Ching-Chu, Wu Vin-Cent, Hung Chi-Sheng, Lin Yen-Hung

Abstract excerpt

Background: Primary aldosteronism (PA) is the leading cause of curable endocrine hypertension, which is associated with a higher risk of cardiovascular and metabolic insults compared to essential hypertension. Aldosterone-producing adenoma (APA) is a major cause of PA, which can be treated with adrenalectomy. Somatic mutations are the main pathogenesis of aldosterone overproduction in APA, of which KCNJ5 somatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels

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Identifiers

PMID: 36950676
DOI: 10.3389/fendo.2023.1061704
PMCID: PMC10025475

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