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Article

KCNJ5 mutation as a predictor for resolution of hypertension after surgical treatment of aldosterone-producing adenoma.

Journal of hypertension - 1 Mar 2018

Kitamoto Takumi, Omura Masao, Suematsu Sachiko, Saito Jun, Nishikawa Tetsuo

Abstract excerpt

OBJECTIVE: To investigate the effect of KCNJ5 mutations on the cure of hypertension in patients with aldosterone-producing adenoma (APA) after unilateral adrenalectomy. METHODS: Our study included 142 patients with APA, who were detected with an endocrinological abnormality and diagnosed with hypertension, as confirmed by pathological analysis. We sequenced KCNJ5, ATP1A1, ATP2B3, CACNA1D, and CTNNB1 from APA...

Read the complete abstract on PubMed

Topics

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Share to Adrenal Cortex Neoplasms
Share to Adrenalectomy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adrenocortical Adenoma

Share to Aldosterone

Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels

Share to Hyperaldosteronism

Share to Hypertension

Share to Hypertrophy, Left Ventricular

Source

Identifiers

PMID: 29016532
DOI: 10.1097/HJH.0000000000001578

Genes

KCNJ5
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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KCNJ5 mutation as a predictor for resolution of hypertension after surgical treatment of aldosterone-producing adenoma.PMID 29016532Read ↗

KCNJ5 Mutation Contributes to Complete Clinical Success in Aldosterone-Producing Adenoma: A Study From a Single Center.Semantic proximity Read ↗

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KCNJ5 gene somatic mutations affect cardiac remodelling but do not preclude cure of high blood pressure and regression of left ventricular hypertrophy in primary aldosteronism.Semantic proximity Read ↗

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Somatic mutations in adrenals from patients with primary aldosteronism not cured after adrenalectomy suggest common pathogenic mechanisms between unilateral and bilateral disease.Semantic proximity Read ↗

Clinical Translationality of KCNJ5 Mutation in Aldosterone Producing Adenoma.Semantic proximity Read ↗

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