Article
An update on the genetic architecture of hyperuricemia and gout.
Arthritis research & therapy - 10 Apr 2015
Merriman Tony R
Abstract excerpt
Genome-wide association studies that scan the genome for common genetic variants associated with phenotype have greatly advanced medical knowledge. Hyperuricemia is no exception, with 28 loci identified. However, genetic control of pathways determining gout in the presence of hyperuricemia is still poorly understood. Two important pathways determining hyperuricemia have been confirmed (renal and gut excretion of...
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