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[DNA sequencing of H3F3A mutations in H3.3 immunohistochemistry-negative giant cell tumors of bone].

Zhonghua bing li xue za zhi = Chinese journal of pathology - 8 Mar 2021

Gong L H, Zhang W, Sun X Q, Zhang M, Ding Y

Abstract excerpt

Objective: To investigate the subtypes of H3F3A DNA mutation in H3.3 immunohistochemistry (IHC) negative giant cell tumors of bone (GCTB). Methods: IHC expression of G34W mutated protein was evaluated in 181 cases GCTB. In H3.3 IHC negative cases, Sanger DNA sequencing analysis was used to detect the subtypes H3F3A mutations. Results: Overall, 164 (90.61%) cases of GCTB showed nuclear expression of H3.3, and 17...

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PMID: 33677880
DOI: 10.3760/cma.j.cn112151-20200601-00426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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