Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SK4 oncochannels regulate calcium entry and promote cell migration in KRAS-mutated colorectal cancer.

Cell calcium - 1 Jun 2021

Ibrahim Sajida, Chaigne Justine, Dakik Hassan, Fourbon Yann, Corset Laetitia, Lecomte Thierry, Raoul William, Guéguinou Maxime

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) metastases are the main cause of CRC mortality. Intracellular Ca2+ regulates cell migration and invasion, key factors for metastases. Ca2+ also activates Ca2+-dependent potassium channels which in turn affect Ca2+ driving force. We have previously reported that the expression of the Ca2+ activated potassium channel KCNN4 (SK4) is higher in CRC primary tumors compared to normal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Cell Movement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Databases, Genetic

Share to HCT116 Cells

Share to HT29 Cells

Share to Proto-Oncogene Proteins p21(ras)

Share to Pyrazoles

Source

Identifiers

PMID: 33676318
DOI: 10.1016/j.ceca.2021.102384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SK4 oncochannels regulate calcium entry and promote cell migration in KRAS-mutated colorectal cancer.PMID 33676318Read ↗

Orai1, a Direct Target of microRNA-519, Promotes Progression of Colorectal Cancer via Akt/GSK3β Signaling Pathway.Semantic proximity Read ↗

The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas.Semantic proximity Read ↗

Orai3 Regulates Pancreatic Cancer Metastasis by Encoding a Functional Store Operated Calcium Entry ChannelSemantic proximity Read ↗

Calcium Channels and Pumps in Cancer: Changes and ConsequencesSemantic proximity Read ↗

Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2.Semantic proximity Read ↗

Colorectal adenocarcinomas downregulate the mitochondrial Na <sup>+</sup> /Ca <sup>2+</sup> exchanger NCLX to drive metastatic spreadSemantic proximity Read ↗

Curcumin and NCLX Inhibitors Share Anti-Tumoral Mechanisms in Microsatellite-Instability-Driven Colorectal CancerSemantic proximity Read ↗

Investigation of Novel Small Molecular TRPM4 Inhibitors in Colorectal Cancer CellsSemantic proximity Read ↗

VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6.Semantic proximity Read ↗

BRAF and NRAS mutated melanoma: Different Ca2+ responses, Na+/Ca2+ exchanger expression, and sensitivity to inhibitors.Semantic proximity Read ↗

Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis.Semantic proximity Read ↗

Creatine kinase brain overexpression protects colorectal cells from various metabolic and non-metabolic stresses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.