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Article

VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6.

Microcirculation (New York, N.Y. : 1994) - 1 Oct 2008

Hamdollah Zadeh M A, Glass Catherine A, Magnussen Anette, Hancox Jules C, Bates David O

Abstract excerpt

OBJECTIVE: Vascular endothelial growth factor (VEGF)-induced vascular permeability has been shown to be dependent on calcium influx, possibly through a transient receptor potential cation channel (TRPC)-mediated cation channel with properties of the TRPC3/6/7 subfamily. To investigate further the...

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Share to Calcium Signaling
Share to Capillary Permeability
Share to Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Dominant

Share to Neovascularization, Physiologic

Share to TRPC Cation Channels

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Share to Vascular Endothelial Growth Factor A

Source

Open in PubMed Open full text

Identifiers

PMID: 18800249
DOI: 10.1080/10739680802220323
PMCID: PMC2635545

Genes

TRPC6
TRPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18800249-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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