Article
Interferon regulatory factor 5 gene variants rs2004640 and rs4728142 are associated with carotid intima media thickness but not with cardiovascular events in rheumatoid arthritis.
Clinical and experimental rheumatology - 1 Jan 2022
Agca Rabia, van Sijl Alper M, Vosslamber Saskia, Voskuyl Alexandre E, Verweij Cor L, Nurmohamed Michael T
Abstract excerpt
OBJECTIVES: Rheumatoid arthritis (RA) is associated with cardiovascular (CV) morbidity and mortality. Interferon regulatory factor 5 (IRF5) gene polymorphisms rs2004640 and rs4728142 have been associated with autoimmune diseases, but also with atherosclerosis. Differences in IRF5 gene expression can lead to the production of different interferons and might play a role in the atherogenic process in RA. METHODS: We...
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