Interferon regulatory factor 5 genetic variants are associated with cardiovascular disease in patients with rheumatoid arthritis.

doi:10.1186/ar4608

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Interferon regulatory factor 5 genetic variants are associated with cardiovascular disease in patients with rheumatoid arthritis.

Arthritis research & therapy - 10 Jul 2014

García-Bermúdez Mercedes, López-Mejías Raquel, Genre Fernanda, Castañeda Santos, Llorca Javier, González-Juanatey Carlos, Corrales Alfonso, Ubilla Begoña, Miranda-Filloy José A, Pina Trinitario, Gómez-Vaquero Carmen, Rodríguez-Rodríguez Luis, Fernández-Gutiérrez Benjamín, Balsa Alejandro, Pascual-Salcedo Dora, López-Longo Francisco J, Carreira Patricia, Blanco Ricardo, Martín Javier, González-Gay Miguel A

Abstract excerpt

INTRODUCTION: Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis and increased cardiovascular (CV) disease risk. Interferon regulatory factor 5 (IRF5) is a regulator of type I interferon induction. Recently, researchers have described an association between multiple single-nucleotide polymorphisms of the IRF5 gene and some rheumatic disorders. In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiovascular Diseases

Share to Genetic Predisposition to Disease

Share to Haplotypes

Share to Interferon Regulatory Factors

Share to Polymorphism, Single Nucleotide

Share to Real-Time Polymerase Chain Reaction

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 25011482
DOI: 10.1186/ar4608
PMCID: PMC4227041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interferon regulatory factor 5 genetic variants are associated with cardiovascular disease in patients with rheumatoid arthritis.PMID 25011482Read ↗

Interferon regulatory factor 5 gene variants rs2004640 and rs4728142 are associated with carotid intima media thickness but not with cardiovascular events in rheumatoid arthritis.Semantic proximity Read ↗

Analysis of IRF5 gene functional polymorphisms in rheumatoid arthritis.Semantic proximity Read ↗

Association of polymorphisms in interferon regulatory factor 5 gene with rheumatoid arthritis: a metaanalysis.Semantic proximity Read ↗

Putative role of functional interferon regulatory factor 5 (IRF5) polymorphism in rheumatoid arthritis in a Korean population.Semantic proximity Read ↗

Associations between interferon regulatory factor 5 polymorphisms and rheumatoid arthritis: a meta-analysis.Semantic proximity Read ↗

Association of IRF5 gene polymorphisms with rheumatoid arthritis in a Tunisian population.Semantic proximity Read ↗

Interferon regulatory factor 5 gene polymorphism confers risk to several rheumatic diseases and correlates with expression of alternative thymic transcripts.Semantic proximity Read ↗

A single nucleotide polymorphism in the IRF5 promoter region is associated with susceptibility to rheumatoid arthritis in the Japanese population.Semantic proximity Read ↗

Association of interferon regulatory factor 5 haplotypes, similar to that found in systemic lupus erythematosus, in a large subgroup of patients with rheumatoid arthritis.Semantic proximity Read ↗

Genetic markers of cardiovascular disease in rheumatoid arthritis.Semantic proximity Read ↗

Preferential association of interferon regulatory factor 5 gene variants with seronegative rheumatoid arthritis in 2 Swedish case-control studies.Semantic proximity Read ↗

The interferon regulatory factor 5 gene confers susceptibility to rheumatoid arthritis and influences its erosive phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.