Article
Variants of the interferon regulatory factor 5 gene regulate expression of IRF5 mRNA in atherosclerotic tissue but are not associated with myocardial infarction.
Arteriosclerosis, thrombosis, and vascular biology - 1 May 2008
Mälarstig Anders, Sigurdsson Snaevar, Eriksson Per, Paulsson-Berne Gabrielle, Hedin Ulf, Wallentin Lars, Siegbahn Agneta, Hamsten Anders, Syvänen Ann-Christine
Abstract excerpt
BACKGROUND: Signaling events after activation of toll-like receptors (TLRs) are important mechanisms promoting inflammation in the atherosclerotic plaque. INF regulatory factor 5 (IRF5) is one of the mediators of downstream effects of TLRs. Several single nucleotide polymorphisms (SNPs) in the IRF5 gene have been found to be associated with systemic lupus erythematosus. METHODS AND RESULTS: We examined IRF5 mRNA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.