Analysis of the interferon gamma (rs2430561, +874T/A) functional gene variant in relation to the presence of cardiovascular events in rheumatoid arthritis.

doi:10.1371/journal.pone.0047166

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Article

Analysis of the interferon gamma (rs2430561, +874T/A) functional gene variant in relation to the presence of cardiovascular events in rheumatoid arthritis.

PloS one - 1 Jan 2012

García-Bermúdez Mercedes, López-Mejías Raquel, González-Juanatey Carlos, Corrales Alfonso, Robledo Gema, Castañeda Santos, Miranda-Filloy José A, Blanco Ricardo, Fernández-Gutiérrez Benjamín, Balsa Alejandro, González-Alvaro Isidoro, Gómez-Vaquero Carmen, Llorca Javier, Martín Javier, González-Gay Miguel A

Abstract excerpt

OBJECTIVE: Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased cardiovascular (CV) morbidity and mortality. Since interferon-gamma (IFN-γ) has a direct effect on inflammation, in this study we assessed the potential association of the IFNG functional gene variant rs2430561 with CV disease in patients with RA. METHODS: One thousand six hundred and thirty-five patients fulfilling...

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Identifiers

PMID: 23077565
DOI: 10.1371/journal.pone.0047166
PMCID: PMC3471910

Genes

IFNG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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