Article
Longitudinal Comparative Analysis of Circulating Tumor DNA and Matched Tumor Tissue DNA in Patients with Metastatic Colorectal Cancer Receiving Palliative First-Line Systemic Anti-Cancer Therapy.
Cancer research and treatment - 1 Oct 2024
Lee Seung-Been, Kim Ji-Won, Kim Hong-Geun, Hwang Sung-Hyun, Kim Kui-Jin, Lee Ju Hyun, Seo Jeongmin, Kang Minsu, Jung Eun Hee, Suh Koung Jin, Kim Se Hyun, Kim Jin Won, Kim Yu Jung, Kim Jee Hyun, Kwon Nak-Jung, Lee Keun-Wook
Abstract excerpt
PURPOSE: This study aimed to compare tumor tissue DNA (ttDNA) and circulating tumor DNA (ctDNA) to explore the clinical applicability of ctDNA and to better understand clonal evolution in patients with metastatic colorectal cancer undergoing palliative first-line systemic therapy. MATERIALS AND METHODS: We performed targeted sequencing analysis of 88 cancer-associated genes using germline DNA, ctDNA at baseline...
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