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Article

Interaction of genetic and lifestyle risk scores on colorectal cancer risk across 5 racial and ethnic populations.

Journal of the National Cancer Institute - 1 Jul 2026

Huang Brian Z, Chen Fei, Bogumil David, Han Sihao, Paik Adelynn, Wan Peggy, Sheng Xin, Siegmund Kimberly D, Peters Ulrike, VoPham Trang, Wang Louise, Alderete Tanya L, Salhia Bodour, Lenz Heinz-Josef, Stram Daniel O, Wilkens Lynne R, Le Marchand Loïc, Conti David V, Haiman Christopher A

Abstract excerpt

BACKGROUND: Integrating genetic and lifestyle information has the potential to greatly improve the prediction of colorectal cancer (CRC) risk. However, racial and ethnic minorities are generally underrepresented in gene-environment studies of CRC risk. METHODS: We investigated the interplay of genetics and lifestyle on CRC risk in a prospective analysis of 68 397 African American, Japanese American, Latino,...

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Identifiers

PMID: 41697998
DOI: 10.1093/jnci/djag045
PMCID: PMC13339091

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