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Neuroimaging Correlates of 3 Distinct Physical-Cognitive Phenotypes in Cognitively Normal Older Adults: The Gothenburg H70 Cohort Study.

Neurology - 14 Jan 2025

Wang Rui, Marseglia Anna, Skoog Johan, Lindberg Olof, Pereira Joana B, Shams Sara, Shams Mana, Kivipelto Miia, Sterner Therese Rydberg, Kern Silke, Zettergren Anna, Skoog Ingmar, Westman Eric

Abstract excerpt

BACKGROUND AND OBJECTIVES: Individuals aged 70 and older frequently experience an increased risk of deficits in both physical and cognitive functions. However, the natural progression and interrelationship of these deficits, as well as their neurologic correlates, remain unclear. We aimed to classify the data-driven physical-cognitive phenotypes and then investigate their associations with neuroimaging markers....

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PMID: 39642342
DOI: 10.1212/WNL.0000000000210121
PMCID: PMC11627174

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