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Article

The promotion of a constructive macrophage phenotype by solubilized extracellular matrix.

Biomaterials - 1 Oct 2014

Sicari Brian M, Dziki Jenna L, Siu Bernard F, Medberry Christopher J, Dearth Christopher L, Badylak Stephen F

Abstract excerpt

The regenerative healing response of injured skeletal muscle is dependent upon a heterogeneous population of responding macrophages, which show a phenotypic transition from the pro-inflammatory M1 to the alternatively activated and constructive M2 phenotype. Biologic scaffolds derived from mammalian extracellular matrix (ECM) have been used for the repair and reconstruction of a variety of tissues, including...

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Identifiers

PMID: 25043569
DOI: 10.1016/j.biomaterials.2014.06.060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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