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Article

Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells.

Nature communications - 26 Feb 2021

Zhang Yao, Lahmann Ines, Baum Katharina, Shimojo Hiromi, Mourikis Philippos, Wolf Jana, Kageyama Ryoichiro, Birchmeier Carmen

Abstract excerpt

Cell-cell interactions mediated by Notch are critical for the maintenance of skeletal muscle stem cells. However, dynamics, cellular source and identity of functional Notch ligands during expansion of the stem cell pool in muscle growth and regeneration remain poorly characterized. Here we demonstrate that oscillating Delta-like 1 (Dll1) produced by myogenic cells is an indispensable Notch ligand for self-renewal...

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Identifiers

PMID: 33637744
DOI: 10.1038/s41467-021-21631-4
PMCID: PMC7910593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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