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Article

Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacity

12 May 2017

Abstract excerpt

Myogenic stem cells are a promising avenue for the treatment of muscular disorders. Freshly isolated muscle stem cells have a remarkable engraftment ability in vivo, but their cell number is limited. Current conventional culture conditions do not allow muscle stem cells to expand in vitro with their bona fide engraftment efficiency, requiring the improvement of culture procedures for achieving successful...

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PMID: 28498863
DOI: 10.1371/journal.pone.0177516

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