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Article

Human Myobundle Platform for Studying the Role of Notch Signaling in Satellite Cell Phenotype and Function.

Advanced healthcare materials - 1 May 2025

Broer Torie, Tsintolas Nick, Hammond Stewart, Helfer Abbigail, Lee Joonbum, Purkey Karly, DeLuca Sophia, Khodabukus Alastair, Bursac Nenad

Abstract excerpt

Notch signaling plays a pivotal role in regulating satellite cell (SC) behavior during skeletal muscle development, homeostasis, and repair. While well-characterized in mouse models, the impact of Notch signaling in human muscle tissues remains largely underexplored. Here, a 3D tissue-engineered model of human skeletal muscle ("myobundles") is utilized as an in vitro platform for temporal control and studies of...

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Share to Calcium-Binding Proteins
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Proteins

Share to Muscle, Skeletal

Share to Receptors, Notch

Share to Satellite Cells, Skeletal Muscle

Share to Signal Transduction

Share to Tissue Engineering

Source

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Identifiers

PMID: 40123310
DOI: 10.1002/adhm.202404695
PMCID: PMC12152250

Genes

DLL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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