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Pathologic and molecular insights in nodal T-follicular helper cell lymphomas

30 Jan 2023

Abstract excerpt

T-follicular helper (TFH) cells are one of the T-cell subsets with a critical role in the regulation of germinal center (GC) reactions. TFH cells contribute to the positive selection of GC B-cells and promote plasma cell differentiation and antibody production. TFH cells express a unique phenotype characterized by PD-1hi, ICOShi, CD40Lhi, CD95hi, CTLAhi, CCR7lo, and CXCR5hi. Three main subtypes of nodal TFH...

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PMID: 36793612
DOI: 10.3389/fonc.2023.1105651

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