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Article

rs1944919 on chromosome 11q23.1 and its effector genes COLCA1/COLCA2 confer susceptibility to primary biliary cholangitis.

Scientific reports - 25 Feb 2021

Hitomi Yuki, Aiba Yoshihiro, Kawai Yosuke, Kojima Kaname, Ueno Kazuko, Nishida Nao, Kawashima Minae, Gervais Olivier, Khor Seik-Soon, Nagasaki Masao, Tokunaga Katsushi, Nakamura Minoru, Tsuiji Makoto

Abstract excerpt

Primary biliary cholangitis (PBC) is a chronic, progressive cholestatic liver disease in which intrahepatic bile ducts are destroyed by an autoimmune reaction. Our previous genome-wide association study (GWAS) identified chromosome 11q23.1 as a susceptibility gene locus for PBC in the Japanese population. Here, high-density association mapping based on single nucleotide polymorphism (SNP) imputation and in...

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Share to Chromosomes, Human, Pair 11
Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Liver Cirrhosis, Biliary

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Identifiers

PMID: 33633225
DOI: 10.1038/s41598-021-84042-x
PMCID: PMC7907150

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