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Article

rs9459874 and rs1012656 in CCR6/FGFR1OP confer susceptibility to primary biliary cholangitis.

Journal of autoimmunity - 1 Jan 2022

Hitomi Yuki, Aiba Yoshihiro, Ueno Kazuko, Nishida Nao, Kawai Yosuke, Kawashima Minae, Yasunami Michio, Gervais Olivier, Ito Masahiro, Cordell Heather J, Mells George F, Nagasaki Masao, Tokunaga Katsushi, Tsuiji Makoto, Nakamura Minoru

Abstract excerpt

Primary biliary cholangitis (PBC) is a chronic cholestatic autoimmune liver disease that appears to be strongly influenced by genetic factors. Recently, an international meta-analysis of genome-wide association studies (GWAS) identified CC-Motif Chemokine Receptor-6 (CCR6) and FGFR1 Oncogene-Partner (FGFR1OP) as PBC-susceptibility genes. However, the lead single nucleotide polymorphisms (SNPs) of CCR6/FGFR1OP...

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PMID: 34864633
DOI: 10.1016/j.jaut.2021.102775

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