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Article

Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program

11 Apr 2018

Abstract excerpt

Tissue and vessel wall stiffening alters endothelial cell properties and contributes to vascular dysfunction. However, whether extracellular matrix (ECM) stiffness impacts vascular development is not known. Here we show that matrix stiffness controls lymphatic vascular morphogenesis. Atomic force microscopy measurements in mouse embryos reveal that venous lymphatic endothelial cell (LEC) progenitors experience a...

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PMID: 29666442
DOI: 10.1038/s41467-018-03959-6

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