Article
The role of PNPLA3 and TM6SF2 polymorphisms on liver fibrosis and metabolic abnormalities in Brazilian patients with chronic hepatitis C.
BMC gastroenterology - 23 Feb 2021
Oliveira Arthur Ivan N, Malta Fernanda M, Zitelli Patricia Momoyo Y, Salles Ana Paula M, Gomes-Gouvea Michele S, Nastri Ana Catharina S, Pinho Joao Renato R, Carrilho Flair J, Oliveira Claudia P, Mendes-Corrêa Maria Cássia, Pessoa Mario G, Mazo Daniel F
Abstract excerpt
BACKGROUND: Despite the growing body of knowledge about TM6SF2 and PNPLA3 polymorphisms in non-alcoholic fatty liver disease, their influence in the spectrum of HCV liver disease is not yet fully defined. Besides that, admixed populations, such as Brazilians, were not included in most of the studies. METHODS: This cross-sectional study enrolled 365 treatment-naïve patients with HCV and 134 healthy individuals....
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