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Article

PNPLA3 and TM6SF2 genetic variants and hepatic fibrosis and cirrhosis in Pakistani chronic hepatitis C patients: a genetic association study.

BMC gastroenterology - 26 Aug 2022

Rauff Bisma, Alzahrani Badr, Chudhary Shafiq A, Nasir Bilal, Mahmood Saqib, Bhinder Munir Ahmad, Faheem Muhammad, Amar Ali

Abstract excerpt

BACKGROUND: The present study investigates if common missense functional variants p.I148M and p.E167K in PNPLA3 and TM6SF2 genes, respectively, associate with development of hepatic fibrosis and cirrhosis in a geographically novel cohort of Pakistani chronic hepatitis C (CHC) patients. METHODS: In total, 502 Pakistani CHC patients [242 males, median age 40 years, 220 with significant hepatic fibrosis, including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36028802
DOI: 10.1186/s12876-022-02469-6
PMCID: PMC9414345

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