Article
Elevated levels of oxidized nucleosides in individuals with the JAK2V617F mutation from a general population study.
Redox biology - 1 May 2021
Sørensen Anders L, Hasselbalch Hans C, Bjørn Mads Emil, Nielsen Claus H, Cordua Sabrina, Skov Vibe, Kjær Lasse, Poulsen Henrik E, Ellervik Christina
Abstract excerpt
It is unknown if the somatic mutations in chronic myeloproliferative neoplasms (MPNs), JAK2V617F and Calreticulin, are associated with oxidative stress, or impaired mitochondrial defense against reactive oxygen species. In the Danish General Suburban Population Study (GESUS), including 116 JAK2V617F-mutated, 8 CALR-mutated, and 3310 mutation-negative participants without overt MPN, and in a study of 39 patients...
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