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Article

The role of genotypes that modify the toxicity of chemical mutagens in the risk for myeloproliferative neoplasms.

International journal of environmental research and public health - 24 Feb 2015

Gross-Davis Carol Ann, Heavner Karyn, Frank Arthur L, Newschaffer Craig, Klotz Judith, Santella Regina M, Burstyn Igor

Abstract excerpt

BACKGROUND: The etiology of myeloproliferative neoplasms (MPN) (polycythemia vera; essential thrombocythemia; primary myelofibrosis) is unknown, however they are associated with a somatic mutation--JAK2 V617F--suggesting a potential role for environmental mutagens. METHODS: We conducted a population-based case-control study in three rural Pennsylvania counties of persons born 1921-1968 and residing in the area...

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Source

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Identifiers

PMID: 25719551
DOI: 10.3390/ijerph120302465
PMCID: PMC4377912

Genes

GSTA1
GSTM3
JAK2
NAT2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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