Article
Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses.
Immunity - 14 Sept 2021
Tang Qiannan, Rigby Rachel E, Young George R, Hvidt Astrid Korning, Davis Tanja, Tan Tiong Kit, Bridgeman Anne, Townsend Alain R, Kassiotis George, Rehwinkel Jan
Abstract excerpt
Nucleic acids are powerful triggers of innate immunity and can adopt the Z-conformation, an unusual left-handed double helix. Here, we studied the biological function(s) of Z-RNA recognition by the adenosine deaminase ADAR1, mutations in which cause Aicardi-Goutières syndrome. Adar1mZα/mZα mice, bearing two point mutations in the Z-nucleic acid binding (Zα) domain that abolish Z-RNA binding, displayed spontaneous...
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