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Article

Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b.

The EMBO journal - 15 Mar 2021

Ercan Bilge, Naito Tomoki, Koh Dylan Hong Zheng, Dharmawan Dennis, Saheki Yasunori

Abstract excerpt

Cholesterol is essential for cell physiology. Transport of the "accessible" pool of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) by ER-localized GRAMD1 proteins (GRAMD1a/1b/1c) contributes to cholesterol homeostasis. However, how cells detect accessible cholesterol within the PM remains unclear. We show that the GRAM domain of GRAMD1b, a coincidence detector for anionic lipids,...

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Identifiers

PMID: 33604931
DOI: 10.15252/embj.2020106524
PMCID: PMC7957428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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