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Article

GoLoco/GPR motif-dependent regulation of Rap1GAP1 by Gαo is disrupted by Gαo encephalopathy variants.

The Journal of biological chemistry - 1 Aug 2025

Momplaisir Nathalie L, Chandan Naincy R, Wang Beiyun, Qu Elaine, Smrcka Alan V

Abstract excerpt

G protein-coupled receptors (GPCRs) that couple to Gαi/o family members are major therapeutic targets. Among heterotrimeric G proteins, Gαo is the most abundant Gα subunit in the brain, but the mechanistic pathways controlled by Gαo have not been thoroughly established. Understanding Gαo-mediated signaling pathways is especially critical given recent reports of a neurodevelopmental disorder (GNAO1 encephalopathy)...

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Identifiers

PMID: 40615045
DOI: 10.1016/j.jbc.2025.110446
PMCID: PMC12329598

Genes

GNAO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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