Article
Stepwise selection of mutation conferring fluroquinolone resistance: multisite MDR-TB cohort study.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Aug 2021
Gao Jingtao, Du Jian, Shu Wei, Liu Yuhong, Wang Yufeng, Xue Zhongtan, Li Liang, Pang Yu
Abstract excerpt
In this study, we demonstrate that fluroquinolone (FQ) is at risk of acquired drug resistance after continuous exposure. The reduced susceptibility is observed in subsequent Mycobacterium tuberculosis isolates from patients without FQ exposure. The stepwise selection of mutation of increasing FQ resistance highlights the urgent need for monitoring FQ resistance in multidrug-resistant tuberculosis patients...
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