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Article

Distinct conformational states mediate the transport and anion channel properties of the glutamate transporter EAAT-1.

The Journal of biological chemistry - 19 Apr 2002

Ryan Renae M, Vandenberg Robert J

Abstract excerpt

Glutamate transport by the excitatory amino acid transporters (EAATs) is coupled to the co-transport of 3 Na(+), 1 H(+), and the counter-transport of 1 K(+) ion. In addition to coupled ion fluxes, glutamate and Na(+) binding to the transporter activates a thermodynamically uncoupled anion conductance through the transporter. In this study, we have distinguished between these two conductance states of the EAAT-1...

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Identifiers

PMID: 11815608
DOI: 10.1074/jbc.M109970200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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