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Analysis of IL-4 promoter and VNTR polymorphisms in Thai patients with pulmonary tuberculosis.

Tropical biomedicine - 1 Dec 2019

Kulpraneet M, Limtrakul A, Thanomtham P, Taemaitree N, Puttikamonkul S, Pongsunk S, Srisurapanon S, Troye-Blomberg M, Tangteerawatana P

Abstract excerpt

Tuberculosis (TB) is a leading cause of morbidity and mortality in Thailand. Cytokines play important roles in defense against Mycobacterium tuberculosis infection. Interleukin (IL)-4 is one of the anti-inflammatory cytokines and has been found to be elevated in TB patients. The common polymorphisms in IL-4 gene, including IL-4-590C/T, IL-4-33C/T, and IL-4-variable number of tandem repeats (VNTR) intron 3 have...

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PMID: 33597460

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