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Article

The effects of IL-27 and IL-35 gene variation and expression levels on the susceptibility and clinical manifestations of pulmonary tuberculosis.

Frontiers in immunology - 1 Jan 2024

Gao Lei, Xiong Yan-Jun, Liang Ya-Xue, Huang Peng-Fei, Liu Shuang, Xiao Yu, Huang Qian, Wang Hua, Wu Hui-Mei

Abstract excerpt

Inflammatory cytokines have crucial roles in the pathogenesis of tuberculosis (TB), and interleukin (IL)-27 and IL-35 have a pro-inflammatory and anti-inflammatory effect on many diseases, including infectious diseases. Therefore, we evaluated the relationship between IL-27 and IL-35 gene polymorphism, expression levels, and pulmonary TB (PTB) susceptibility. Nine single-nucleotide polymorphisms (SNPs) in the...

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PMID: 38690286
DOI: 10.3389/fimmu.2024.1267624
PMCID: PMC11058845

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