Article
rs2243268 and rs2243274 of Interleukin-4 (IL-4) gene are associated with reduced risk for extrapulmonary and severe tuberculosis in Chinese Han children.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Apr 2014
Qi Hui, Sun Lin, Jin Ya-Qiong, Shen Chen, Chu Ping, Wang Sheng-Feng, Yin Qing-Qin, Qi Zhan, Xu Fang, Jiao Wei-Wei, Wu Xi-Rong, Tian Jian-Ling, Xiao Jing, Shen A-Dong
Abstract excerpt
Interleukin-4 (IL-4) and IL-10, which are produced by Th2 cells, serve as anti-inflammatory cytokines in the immune responses to tuberculosis (TB). In order to investigate the association between susceptibility to TB and single-nucleotide polymorphisms (SNPs) of the IL-4 and IL-10 genes, a case-control study including 346 TB patients and 374 healthy controls was performed in Chinese Han children in North China....
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