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Mutant analysis of Kcng4b reveals how the different functional states of the voltage-gated potassium channel regulate ear development.

Developmental biology - 1 Sept 2024

Jędrychowska Justyna, Vardanyan Vitya, Wieczor Milosz, Marciniak Antoni, Czub Jacek, Amini Razieh, Jain Ruchi, Shen Hongyuan, Choi Hyungwon, Kuznicki Jacek, Korzh Vladimir

Abstract excerpt

The voltage gated (Kv) slow-inactivating delayed rectifier channel regulates the development of hollow organs of the zebrafish. The functional channel consists of the tetramer of electrically active Kcnb1 (Kv2.1) subunits and Kcng4b (Kv6.4) modulatory or electrically silent subunits. The two mutations in zebrafish kcng4b gene - kcng4b-C1 and kcng4b-C2 (Gasanov et al., 2021) - have been studied during ear...

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PMID: 38492873
DOI: 10.1016/j.ydbio.2024.03.002

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