Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated geneGREM2regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm

Abstract excerpt

Atrial fibrillation (AF) is the most common cardiac arrhythmia and carries a significant risk of stroke and heart failure. The molecular etiologies of AF are poorly understood, leaving patients with limited therapeutic options. AF has been recognized as an inherited disease in almost 30% of patient cases. However, few genetic loci have been identified and the mechanisms linking genetic variants to AF...

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