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PLA2R1 Mediates Tumor Suppression by Activating JAK2

5 Sept 2013

Abstract excerpt

Little is known about the physiological role of the phospholipase A2 receptor (PLA2R1). PLA2R1 has been described as regulating the replicative senescence, a telomerase-dependent proliferation arrest. The downstream PLA2R1 signaling and its role in cancer are currently unknown. Senescence induction in response to activated oncogenes is a failsafe program of tumor suppression that must be bypassed for...

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PMID: 24008317
DOI: 10.1158/0008-5472.can-13-0318

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