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Article

Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model.

mBio - 16 Feb 2021

Roubidoux Ericka Kirkpatrick, Carreño Juan Manuel, McMahon Meagan, Jiang Kaijun, van Bakel Harm, Wilson Patrick, Krammer Florian

Abstract excerpt

Current seasonal influenza virus vaccines target regions of the hemagglutinin (HA) head domain that undergo constant antigenic change, forcing the painstaking annual reformulation of vaccines. The development of broadly protective or universal influenza virus vaccines that induce cross-reactive, protective immune responses could circumvent the need to reformulate current seasonal vaccines. Many of these vaccine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33593972
DOI: 10.1128/mBio.03617-20
PMCID: PMC8545130

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