Article
Epitope dampening monotypic measles virus hemagglutinin glycoprotein results in resistance to cocktail of monoclonal antibodies.
PloS one - 1 Jan 2013
Lech Patrycja J, Tobin Gregory J, Bushnell Ruth, Gutschenritter Emily, Pham Linh D, Nace Rebecca, Verhoeyen Els, Cosset François-Loïc, Muller Claude P, Russell Stephen J, Nara Peter L
Abstract excerpt
The measles virus (MV) is serologically monotypic. Life-long immunity is conferred by a single attack of measles or following vaccination with the MV vaccine. This is contrary to viruses such as influenza, which readily develop resistance to the immune system and recur. A better understanding of factors that restrain MV to one serotype may allow us to predict if MV will remain monotypic in the future and...
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